Prof. Shosh Ravid

IMRIC Researcher , Biochemistry & Molecular Biology, IMRIC

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Why I became a researcher: 

Metastasis, the spread of cancer from its tissue of origin and its subsequent growth in other organs is main cause of morbidity and mortality in patients with cancer. The process of metastasis was so intriguing to me and important for the treatment of cancer patients, that it was natural for me that my lab at the Hebrew University that I established after my postdoctoral training investigates this process.

To migrate, cells need to operate a dynamic cytoskeleton composed of many proteins to produce the necessary protrusions and forces that drive the cell forward. In cancer cells the dynamics and regulation of the cytoskeleton is corrupted at several levels. My lab investigates the alterations in the cytoskeletal proteins in tumor cells and how these alterations allow tumor cells to invade tissues surrounding the original tumor.

Recently we discovered that the tumor suppressor protein Lgl1 that its low expression in tumor cells correlates with poor prognosis plays a major role in directed cell migration. The absence of Lgl1 results in fast migrating tumor cells (Dahan et al. (2012), Mol. Biol. Cell. 23: 591-601).

Education: 

1986-1990: Post-doctoral fellow in Cell Biology - Department of Cell Biology, Stanford University School of Medicine, Stanford, California, USA.

1986-1990: Post-doctoral fellow in Cell Biology - Department of Cell Biology, Stanford University School of Medicine, Stanford, California, USA.

1982-1986: Doctorate in Biology - Department of Membrane Research, The Weizmann Institute of Science Rehovot, Israel.

1979-1982: Master in Microbiology - Department of Microbiology, Tel-Aviv University, Israel.

1976-1979: Bachelor in Biology - Faculty of Life Science, Tel-Aviv University, Israel; Bachelor in Biology.

Contact: 
shoshr [at] ekmd [dot] huji [dot] ac [dot] il