Dr. Rotem Karni
Senior Lecturer (Assistant Professor) at the Department of Biochemistry and Molecular Biology
, Biochemistry & Molecular Biology, IMRIC
My interest in science began when I was a small child in Kibbutz Ramat Hashofet in the north of Israel. I used to catch reptiles and insects just so I could learn about them. My curiosity turned into ambitions of becoming a zoologist. I had dreams of studying animals in the South American rain forests. In order to pursue these dreams I began studying biology at The Hebrew University of Jerusalem. That’s where I fell in love with genetics and biochemistry. I specifically wanted to understand why and how cancer develops and progresses, affecting the lives of so many people around the world.
Today, in my lab at IMRIC we are interested in how the process of alternative RNA splicing (a fundamental step of gene expression) is de-regulated in cancer and other diseases, and how the proteins that control this process (called splicing factors) contribute to cancer development, tumor progression and the metastatic process.
Some of our findings on new cancer therapies and diagnostic tools are currently being developed by the Hebrew University technology transfer company Yissum.
2003-2008: Post-Doctoral training, Cold Spring Harbor Laboratory, NY
2003: PhD in Biological Chemistry, The Hebrew University of Jerusalem
1996: B. Sc in Biology, The Hebrew University of Jerusalem
Mechanism Involved In Breast Cancer Cell Growth Discovered By Hebrew University IMRIC Researchers Provides Opening For Early Detection, Treatment
Researchers at the Hebrew University Institute of Medical Research Israel-Canada have discovered a new mechanism by which breast cancer cells switch on their aggressive cancerous behavior. The discovery provides a valuable marker for the early diagnosis and follow-up treatment of malignant growths.
An Israeli postdoctoral fellow has identified a genetic protein likely to be involved in the development and spread of glioblastoma, the most common and aggressive type of brain cancer in adults.
Jerusalem Post Article On IMRIC: "Jerusalem Researchers Discover How Cancerous Tumors Become Resistant To Drugs"
Breakthrough is crucial to enabling the rapidly developing field of “personalized medicine” in cancer treatment.